- Students bring their prepared peptide/protein sequence (aka beads on a pipe cleaner) to the Golgi apparatus for sequence recognition and folding instruction
- Students fold their pipe cleaner protein according to the model
- Students cross the finish line/cell membrane with their final secreted, folded, accurate protein as mastery of the Escape the Cell challenge
Further discussion can include exploration of protein folding diseases and other protein functions in the cytoplasm, membranes, organelles, etc.
This could also be an opportunity to talk about the difference between mutations to DNA and effects to protein form and function.
If you had one mis-colored or missed bead on your amino acid sequence, could you still properly identify the protein shape you needed to fold? Could this happen in your cells too? What might be the effects?